CLINICAL UPDATES
from SpectraCell Laboratories, Inc.

Volume 2007 - Issue 04 - December 2007

SpectraCell Welcomes Dr. Wei Sun, Ph.D., M.D. to our Scientific Staff.

In this issue...

• Vitamin D Protects Against Colon Tumors
• Omega 3 Fatty Acids Guard Against Type I Diabetes
• LDL Particle Size Affects Rate of Stenosis
• Supplement Users Have Better Blood Chemistry
• Vitamin A Improves Cognitive Function
• Low Vitamin B12 May Exacerbate Dementia
• Betaine and Choline May Lower Homocysteine

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CLINICAL UPDATE – Vitamin D Protects Against Colon Tumors
But vitamin D does not protect against most cancers, says study
(Journal of the National Cancer Institute, November 2007)
Link to NEWS SUMMARY
LINK to ABSTRACT Prospective study of serum vitamin D and cancer mortality in the United States

CLINICAL UDPATE – Omega 3 Fatty Acids Guard Against Type I Diabetes
High risk kids who ate more fatty acids were less likely to develop diabetes
(Journal of the American Medical Association, September 2007)
Link to NEWS SUMMARY
LINK to ABSTRACT Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type I diabetes

CLINICAL UPDATE – LDL Particle Size Affects Rate of Stenosis
Small, Dense LDL increases stenosis and accumulation of oxidized LDL in the aortic valve
(Arteriosclerosis, thrombosis, and vascular biology, November 2007)
Link to ABSTRACT Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis

CLINICAL UPDATE –Supplement Users Have Better Blood Chemistry
They showed better homocysteine, CRP, triglycerides, HDL and blood pressure values
(Nutrition Journal, October 2007)
Link to ABSTRACT Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study.
Link to FULL PAPER

CLINICAL UPDATE –Vitamin A Improves Cognitive Function
Randomized trial shows cognitive benefits in men for long-term supplementation
(Archives of Internal Medicine, November 2007)
Link to ABSTRACT A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II.

CLINICAL UPDATE –Low Vitamin B12 May Exacerbate Dementia
Vitamin B12 status predicted cognitive decline in older adults, but folate did not
(American Journal of Clinical Nutrition, November 2007)
Link to ABSTRACT Low vitamin B-12 status and risk of cognitive decline in older adults.

CLINICAL UPDATE – Betaine and Choline May Lower Homocysteine
Benefits are even more pronounced in women with low folate intake
(American Journal of Clinical Nutrition, October 2007)
Link to ABSTRACT The association between betaine and choline intakes and the plasma concentrations of homocysteine in women