CLINICAL UPDATES
from SpectraCell Laboratories, Inc.

Volume 2008, Issue 06 - June 2008

In This Issue….

• Vitamins C and E lower blood pressure
• Vitamin D and breast cancer: sunlight or supplements?
• Lp(a) is dangerous regardless of weight
• Unstable carotid plaque marked by high Lp-PLA2
• Vitamin C protects muscles after exercise
• Carnitine reduces fatigue in elderly
• Calcium and vitamin D linked to lower rates of hypertension

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CLINICAL UPDATE - Vitamins C and E lower blood pressure
Study supports the hypothesis that oxidative stress is involved in the etiology of essential hypertension
(Clinical Science, May 2008)
LINK to ABSTRACT Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

CLINICAL UPDATE - Vitamin D and breast cancer: sunlight or supplements?
Higher vitamin D levels from exposure to sunlight, specifically UVB may reduce the incidence of breast cancer, according to a new study
(Breast Journal, May 2008)
(Journal of the American Academy of Dermatology, 2002 and 2003)
LINK to NEWS STORY
LINK to ABSTRACT Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries
LINK to ABSTRACT The evolution of current medical and popular attitudes toward ultraviolet light exposure: part 1.
LINK to ABSTRACT The evolution of current medical and popular attitudes toward ultraviolet light exposure: part 2.
LINK to ABSTRACT The evolution of current medical and popular attitudes toward ultraviolet light exposure: part 3.

CLINICAL UPDATE - Lp(a) is dangerous regardless of weight
Lipoprotein(a) levels are linked to heart disease even after adjustment of metabolic risk factors like waist circumference and insulin resistance
(Coronary Artery Disease, May 2008)
LINK to ABSTRACT Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome

CLINICAL UPDATE - Unstable carotid plaque marked by high Lp-PLA2
Study shows that atherosclerotic plaque under oxidative stress and inflammation had higher levels of lipoprotein-associated phospholipase A2 than stable plaques
(Stroke, May 2008)
LINK to ABSTRACT Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques

CLINICAL UPDATE - Vitamin C protects muscles after exercise
Study demonstrates benefit of vitamin C supplements on lipid peroxidation and muscle damage after endurance exercise
(Journal of Sports Medicine and Physical Fitness, June 2008)
LINK to ABSTRACT Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% v.o(2max)

CLINICAL UPDATE -Carnitine reduces fatigue in elderly
Study demonstrates improvement in physical fatigue and cognitive functions in elderly patients that took acetly L-carnitine
(Archives of Gerontology and Geriatrics, April 2008)
LINK to ABSTRACT Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue

CLINICAL UPDATE - Calcium and Vitamin D linked to lower rates of hypertension
Study follows over 28,000 women and finds inverse relationship between dairy, vitamin D and calcium intake and the risk for hypertension
(Hypertension, April 2008)
LINK to ABSTRACT Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women